ES - Epidural Stimulation for Spinal Injury

BBH Treatment Program

Epidural Stimulation Program is a customized treatment program plan for individual condition.

The expected benefits of ES are

• Decrease chronic back pain
• Overall sense of improved quality of life.
• Improvement in regulation of temperature.
• Enhancement in sexual function.
• Increase in bladder control.
• Improvement in certain leg movements.

History of Epidural Stimulation for Spinal Cord Injury

Background Knowledge

Complete paralysis condition from Spinal cord injury was long been admitted that there was no current treatment option available to regain the voluntary motor control. The suffering patients were mostly admitted with the lifelong wheelchair fate. Repeated training sessions, no matter how many and how long, in paralyzed limbs were proved to show no gain by electrophysiology assessment and mostly be eventually given up by despairing patients and practitioners. Medical practitioners and suffering spinal cord injury patients have long surrendered to the fate of complete paralysis from spinal cord injury due to no treatment option available up to now. It was welled noted that no matter how many training sessions provided to the paralyzed limbs, gaining in motor control , clinically or electro physic logically, cannot be expected. Most patients and practitioners eventually quit the effort to train. Most of patients and practitioners eventually quit the training and admit the fate of life long wheel chair bound.

<p ">Over the past 30 years, it had been demonstrated in several animal and human models that spinal cord of mammals can locally generate locomotor output, independently from brain central pattern generation. Simulation of inputs, through training session of limbs or direct intra spinal electrical stimulation can affect the spinal locomotor expression pattern. These collective evidences of existed spinal electrical circuit formed the hypothesis that direct electrical stimulation on lumbosacral spinal cord , together with continuous task specific locomotor training sessions, may help facilitating the standing and stepping in individuals with complete spinal cord injury. There were also several of in vitro studies that keep confirming this possibility. The recent breakthrough of neuromodulation technique, by epidural electrical stimulation, were shown to partially regain voluntary motor control, even not yet fully control

In, 2011there was the report of a spinal cord injury man, 23 year old, who got the traumatic subluxation of spine at level C7-T1, with complete loss of motor function but with partially preserved sensory below T1 segment. He was implanted with epidural 16 electrode array, 3 years after the initial injury. He pursued following 170 locomotor training sessions along with spinal cord stimulation. After 7 months, he later achieved full weight bearing standing for 4.25 minutes with minimal balance support. He also demonstrated stepping locomotor patterns. Apart from that, he reported the recovery of voluntary control of some leg movements while on epidural stimulation.

In 2014, a report from France of another complete spinal cord injury patient, implanted with the functional electrical stimulation (FES) system, which consist of 8 channel epimysia and 4 channel neural stimulators. The system was slightly different from the previous report but still carry the same concept and principles. The patient still benefited from the system, with relevant clinical and electrophysiological evaluations confirmation of findings, even after nine year of the device implantation.

Recently, another exciting report was coming up on April 2014, the same group of U.S. researchers from 2011 reported three more spinal cord injury males showed voluntary movement with epidural stimulation ,some even regain the movement immediately after electrode implantation. The report once again demonstrated that direct electrical stimulation of spinal cord together with task specific locomotor training sessions enable the completely paralyzed spinal cord injury patients to process the conceptual, visual and auditory signals to partially regain voluntary control of paralyzed muscle.

Apart from those, these patients also reported gaining in bladder control, improved sexual response and performance. The overall sense of wellbeing and self-esteem were also increased. These researchers concluded that the combination of lumbosacral spinal network electrical stimulation, at subthreshold motor state, together with the task specific locomotor training sessions were the key to partially recover the voluntary motor function in four of four individuals.

This evolving concept, particularly in early of year 2014, has led us to the era of uncovering the treatment strategy that can dramatically recover voluntary motor control in complete paralyzed spinal cord injury, even years after injury.